Blog Archives

TF3.0 – Using Estimated/Semi-Quan Amounts

In certain parts of TraceFinder and LabForms, we had exposed the ability to use estimated amounts of substances that did not have their own calibration curve. This feature goes back to the days of the Incos data systems, circa 1980.

In TF 3.0 we have exposed this capability, to be a bit more friendly to use and to be interactive in the user interface, versus just report generated.

In the following video, you will see where to set a compound to use the estimated feature and how it is displayed throughout the applications with visual clues to help you determine that the results you are observing is a semi-quantitative amount.

If the video is blurry please click the cog wheel at the bottom of the panel and increase the video display resolution.

Intelligent Sequencing – Step One – Setting up the method

Intelligent Sequencing is not a new concept. In the late 90’s Thermo had an application called ToxLab which used the concept of flagging data and altering the sequence of the set of samples based on failure criteria.

This allows for insertion of blanks, reinjection of sample or a combination according to criteria that a chemist would normal use to look at his data the next day to determine, which if any samples had to be rerun.

Intel Seq just does this on the fly.

It allows the user to have confidence that the data will be handled in the prescribed manner using the existing on the fly criteria that has existed in TraceFinder for a number of years.

By using this feature the chemist can cut back time on reinjections and sometimes on sample prep since the sample wouldn’t have evaporated. Also it will not have gone beyond the sample stability time threshold before reinjection occurs.

The first part of the operation is setting flagging criteria as you have done previously.

The next is setting of the method criteria for Intel Sequencing.

If the video is blurry please click the cog wheel at the bottom of the panel and increase the video display resolution.

TF 3.0 has some new homes for some functions previously available

Part of the process of looking at User Interface changes, is being able to make sure that we present a logical way of navigating to things, that we may not use on a regular basis. This makes it easier for the end user to remember where to get to that special function, when they need it.

So in the application we still have many right click options, but we have also moved many of the scattered functions into the menu drop downs.

These changes have come from customer request or questions about where functions are.

So here are the most used functions that are not directly data linked.

If the video is blurry please click the cog wheel at the bottom of the panel and increase the video display resolution.

TF 3.0 Export Results Grid to Excel and Copy Images to Clip Board

Sticking to new features in data review, we’ll continue with a simple workflow.

One of the many request that TraceFinder has received over the last year has been to have the ability to export the results grid directly to Excel instead of having a Custom Report generated.

In TF 3.0 all data grid results whether in the quantitative views or targeted screening section, export all data to Excel or CSV files directly.

No need to produce a custom report and navigate through the files menus to go get it.

Simply export and place the file where you want it.

Also a feature that has been requested is the ability to copy high definition images of chromatograms and such to the clipboard for use in papers, lab notebooks and presentations/posters.

We also did this in TF 3.0

If the video is blurry please click the cog wheel at the bottom of the panel and increase the video display resolution.

 

New TF 3.0 Targeted Screening Workflow in Data Review (or the marriage of TF and ExactFinder)

A new feature to TraceFinder 3.0 is targeted screening. The workflow and method setup that were included in ExactFinder has been included in TraceFinder 3.0. Though it has been expanded to support Nominal Mass as well as HRAM.

That means this feature will work for all mass spectrometers from the GC single quads to the Q-Exactive.

Though some sections are more geared for HRAM, they can just not be used when using nominal mass data.

The other aspect is that TF gives you the ability to acquire, process and report on the fly during acquisition. Therefore, if you so choose you don’t have to wait to review your data. So this expands the capabilities that was introduced in ExactFinder.

This is our first step with this functionality and more is to come in following releases, but there are some interesting things that can be done by having these two workflows combined.

Again the video is a little longer that my 2 minute rule but there is a lot to look forward to.

If the video is blurry please click the cog wheel at the bottom of the panel and increase the video display resolution.

Associating another batch’s Calibration Curve to the current batch – (Answer to a “Ask A Guru” Question)

I think that the questions below are pretty self explanitory of the feature in the video.

What would you like to know?: Hi, Jamie,

 

Example: A Cal curve batch is acquiring. 

 

Case 1:  I submit a new batch of just patient samples and forget to extend the cal file to those samples.  How do I extend the cal file to those samples w/o pulling them into the Cal Curve batch?

 

Case 2:  I submit a new batch of just patient samples and  extend the cal (with the wrong file) to those samples.  How do I  reprocess with the correct cal file?

Company: TFS

Area Of work: Clinical”

So if you have a batch in flight. You should pause the acquisition while you associate a calibration file. It just makes things cleaner if you have an older system with less RAM.

The video is out of the soon to be released TF 3.0, but if you are using and older version the functionality and menu selections are still the same. Dependant on the resolution setting the last frame may be overlayed with another.

If the video is blurry please click the cog wheel at the bottom of the panel and increase the video display resolution.

What the Heck is ACTIVE VIEW??????(Answer to a “Ask A Guru” question)

Active View is another visualization of the data that is on a Sample Centric Report. These are only availible today on samples that display chromatograms for compounds and contain grouped sample information.

Sucha as the High Density Reports, in the standard reports section of Report View.

When using Report View we generate a temporary view of the report that would be produced by the system. This view is only for the supplied Standard reports delivered with TF and is not available with Custom Reports, today. (Hint be looking to the future.)  😉

But when the report is generated in preview mode, and it has an ActiveView partner, the Active View tab will appear next to it.

In the Active View tab, you will see a grid of data that corresponds with data on the Report and the same Detailed Editing elements in Data Review, with the same functionality.

When data is changed in Active View it is just like editing in Data Review and results are updated.  When this happens and indicator appears to let you know new results are availible for the report. Once clisked the Report is updated. The information is saved. In this manner you can use Report View as your data editor and see exactly what you are giving your clients in real time. You can at this point choose to generate the report, or make all your edits and then generate the reports in a batch process.

If the video is blurry please click the cog wheel at the bottom of the panel and increase the video display resolution.